RNA Details
Disease Name
endomyocardial fibrosis
Tissue
heart
RNA Symbol
mir-133a-1
RNA ID
RNA Type
miRNA
Alteration Pattern
down regulation
Species
mus musculus
Detection Methods
PCR; immunofluorescence etc.
Target
SRF;CCTGF
Pathway
NA
PubMed ID
Title
Regulation of Connective Tissue Growth Factor and Cardiac Fibrosis by an SRF/MicroRNA-133a Axis
Year
2015
Function
miR-133a acts as a repressor of SRF and CTGF expression; A simultaneous overexpression of SRF by ADSRF-VP16 and inhibition of miR-133a by a specific antimiR increase CTGF expression; miR-133a overexpression can block the upregulation of CTGF.